The adrenal glands don’t really get ‘tired’ in the way that you might expect. What happens is that, after a period of chronic stress, your body starts to run out of the hormone precursor material that it uses to make certain hormones. As this continues, it becomes more and more difficult for your body to produce the required levels of stress hormones, sex hormones, and other hormones and neurotransmitters. That’s when the ‘fatigue’ starts to kick in, and that’s when you need to offer your body some extra support.
--- Stress is often mentioned by CSS patients around the time of their diagnosis, and in a way this seems related to the adrenal glands as well. A patient in another support group reported reading in "The Stress of Life" by Dr. H. Seyle:.... "the adrenal glands are the processors of stress in our bodies. A person's stress resistance will vary with the competence of his adrenals. Continually stressing them, finally depletes them. When we become exhausted by life, on a mental or physical level, our adrenal glands often fail to keep up, and illness ensues".