Nandrolone decanoate hormone replacement therapy

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Nandrolon , auch 19-Nortestosteron, ist ein anaboles Steroid . Es beeinflusst wie Testosteron die Entwicklung der männlichen Geschlechtsorgane und den Eiweißaufbau in der Muskulatur . Beim durchschnittlichen Mann ist das Verhältnis im Körper von Testosteron zu Nandrolon 50:1. Da Nandrolon eine wesentlich höhere Aktivität als Testosteron aufweist und das Verhältnis zwischen virilisierender Wirkung und anaboler Wirkung zugunsten des Stoffwechseleffekts verschoben ist, ist es als Dopingmittel von größerem Interesse. Trenbolon ist ein Abkömmling des Nandrolon. Nandrolon wird im Organismus aus Testosteron durch Oxidation der Methylgruppe in Position 10 und anschließender Retro- Claisen-Umlagerung synthetisiert.

Due to its chemical structure nandrolone is weakly exposed to aromatase (only 20% of the aromatizing activity of testosterone).  However, not estrogenic effects are its main concern:  nandrolone has a potent progestogenic activity (20% of progesterone).  While binding to progestogenic pituitary receptors nandrolone causes increased production of prolactin, which in effect is very similar to estrogen: its effect presents in reducing testosterone production, increasing fat mass and in gynecomastia. To prevent these side effects prolactin inhibitors (cabergoline) shall always be at hand when on nandrolones cycle.

Nandrolone decanoate hormone replacement therapy

nandrolone decanoate hormone replacement therapy

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