Nandrolone Phenylpropionate (NPP) is the lesser known and less popular phenylpropionate ester version of nandrolone. First off its important to understand the difference between what we know as 'deca' and what we know as "NPP". To put it in simple terms the difference is simply the ester. NPP has the shorter ester while deca durabolin version of nandrolone has the longer 'deca' ester. Many lifters have no clue they can use the compound they love so much in a shorter ester. The only disadvantage would be the amount of injections, the shorter ester would have to be injected every other day or every 3 days at the most, while the long 'deca' ester can be injected once or twice a week. However the advantages are there which I will discuss as we go along.
There are possible estrogenic side effects of Nandrolone despite it not being a very estrogenic hormone, at least not directly. Nandrolone does aromatize slightly. Aromatization refers to the conversion of testosterone to estrogen . This takes place when the testosterone hormone interacts with the aromatase enzyme. When the conversion takes place this can cause estrogen levels to go up, which can promote gynecomastia and water retention. High blood pressure can also become an issue if water retention becomes severe. Along with the low level of aromatase activity Nandrolone is also a progestin and has a strong binding affinity for the progesterone receptor. This may stimulate the mammary tissue and enhance the risk of gynecomastia in sensitive individuals.
Combating the estrogenic side effects of Nandrolone can be achieved by the use of anti-estrogen medications, specifically Aromatase Inhibitors (AI’s) such as Anastrozole ( Arimidex ). Selective Estrogen Receptor Modulators (SERM’s) are also sometimes used, such as Tamoxifen ( Nolvadex ). However, AI’s are the proper choice as they will directly reduce serum estrogen levels and SERM’s will not. An AI should be enough to reduce and avoid gynecomastia unless the individual already has existing gynecomastia that could potentially be exasperated.
Important Note: It’s often been said that Nandrolone based gynecomastia is based on increases in prolactin. It is true that 19-nor steroids can increase prolactin, which can also negatively affect libido and erection function. Some men may need to use a dopamine agonist to combat this. However, it is not prolactin that causes 19-nor based gynecomastia but rather the imbalance between estrogen and progesterone. If you merely combat prolactin you may find yourself with the very gynecomastia you tried to avoid.
Methandienone (also known as methandrostenolone, Dbol, dianabol) is an orally-effective anabolic steroid originally developed in Germany and released in the US in the early 1960s by Ciba Specialty Chemicals. This is a derivative from testosterone, one of the most popular steroid compounds in the world and the second steroid (after testosterone) ever produced. Methandienone promotes dramatic increases in protein synthesis, glycogenolysis, and muscle strength over a short space of time.