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It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Akhtar made a successful return to cricket in his first game in the Indian Premier League , playing for the Kolkata Knight Riders against the Delhi Daredevils . Defending a low score of 133 runs, Akhtar took four top order wickets which ultimately led to the Daredevils being restricted to 110 runs. He ended with figures of 4 wickets for 11 runs from three overs, a performance which earned him the player of the match award.   Akhtar denied that he had any point to prove with his performance, stating, "I just wanted to win the game." Knight Riders' captain Sourav Ganguly also acknowledged Akhtar's performance, "He came to the country with lots [of things] happening behind him...But he showed a lot of character."  It has been widely reported that the Knight Riders have released Akhtar from his contract due to his injury history but the Knight Riders' officials have denied these reports and said they are still in talks with the fast bowler.