Almost all of the clinical trials studying TRT have been inconclusive or have not followed patients long-term, so this treatment option is still a bit experimental in practice, and the treatment should not be administered to anyone not deemed an exceptional candidate. Because of the serious nature of TRT, patients with less severe testosterone deficiencies may look into safer, alternative treatment options. Any man currently taking TRT needs to see their doctor regularly for checkups, and should report any medical issues immediately. In addition, prostate screenings are essential.
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But I'm not more aggressive—a behavior change often tied to testosterone. That's not surprising to Robert Sapolsky, ., a neuroendocrinologist at Stanford University and a leading researcher on stress and behavior. "It's really not the case that testosterone 'causes' aggressive behavior," he says. "Instead, it makes the brain more sensitive to social cues that trigger aggression. And in support of that, a guy's testosterone level isn't a very good predictor of how likely he is to be aggressive."
The five observational studies and the Xu meta-analysis were discussed at a joint meeting of the Bone, Reproductive and Urologic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee on September 17, 2014. Based on these findings, the advisory committee members were in general agreement that the signal of cardiovascular risk is weak and that only a prospective, well-controlled clinical trial could determine whether testosterone causes cardiovascular harm. The Corona study was recently published and could not be reviewed in time to be presented at the Advisory Committee meeting; however, we have reviewed the study and factored its findings into our overall assessment.