Haldol depot injectie

Following concomitant administration of carbamazepine, a strong inducer of CYP3A4, and oral aripiprazole to patients with schizophrenia or schizoaffective disorder, the geometric means of C max and AUC for aripiprazole were 68 % and 73 % lower, respectively, compared to when aripiprazole (30 mg) was administered alone. Similarly, for dehydro-aripiprazole the geometric means of C max and AUC after carbamazepine co-administration were 69 % and 71 % lower, respectively, than those following treatment with aripiprazole alone. Aripiprazole dose should be doubled when concomitant administration of aripiprazole occurs with carbamazepine. Concomitant administration of aripiprazole and other inducers of CYP3A4 (such as rifampicin, rifabutin, phenytoin, phenobarbital, primidone, efavirenz, nevirapine and St. John's Wort) may be expected to have similar effects and similar dose increases should therefore be applied. Upon discontinuation of strong CYP3A4 inducers, the dosage of aripiprazole should be reduced to the recommended dose.

WARNING: Increased Mortality in Elderly Patients with Dementia-Related Psychosis
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of 17 placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in the drug-treated patients of between to times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about %, compared to a rate of about % in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (., heart failure, sudden death) or infectious (., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. RISPERDAL CONSTA ® is not approved for the treatment of patients with dementia-related psychosis.

The selected site is cleansed with an antimicrobial and is allowed to dry. It is injected with the dominant hand using a quick, darting motion perpendicular to the patient's body at an angle between 72 and 90 degrees, as a faster injection is less painful. The needle is then stabilized with the nondominant hand while the dominant hand slides to the plunger to slowly instill the medication, as a rapid injection causes more discomfort. The CDC does not recommend the outdated practice of aspirating for blood to rule out injecting into a blood vessel. The needle is withdrawn at the same angle inserted. Using the "Z track" or zigzag technique is recommended, where the skin is pulled and held down to one side with the nondominant hand about an inch and after the needle is withdrawn the displaced skin is allowed to return to its normal position. This is to ensure that the medication does not leak back along the needle track. Gentle pressure is applied with a gauze but the site is not massaged to prevent forcing the medication into subcutaneous tissue. [5]

The majority of depot injections include biodegradable polymer-excipients which serve to manage the medication’s rate of release into the body. Polymer-excipients are inert substances that dilute the drug. Substances delivered by this method can often last for weeks and months, with certain formulas lasting considerably longer. People suffering from prostate cancer are typically given depot injections as a way of receiving hormone therapy and treatments. Depot injections are usually oil or solid based and can sometimes create a localized area of pain and swelling which can last for a few days.

Haldol depot injectie

haldol depot injectie

The majority of depot injections include biodegradable polymer-excipients which serve to manage the medication’s rate of release into the body. Polymer-excipients are inert substances that dilute the drug. Substances delivered by this method can often last for weeks and months, with certain formulas lasting considerably longer. People suffering from prostate cancer are typically given depot injections as a way of receiving hormone therapy and treatments. Depot injections are usually oil or solid based and can sometimes create a localized area of pain and swelling which can last for a few days.

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